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KMID : 0043320120350040617
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Archives of Pharmacal Research
2012 Volume.35 No. 4 p.617 ~ p.621
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Neuroprotective compounds isolated from Cynanchum paniculatum
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Weon Jin-Bae
Kim Chul-Young
Yang Hye-Jin
Ma Choong-Je
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Abstract
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Ten compounds were isolated from the 80% methanol extract of roots of Cynanchum paniculatum Kitagawa (Asclepiadaceae) and identified as paeonol (1), 4-acetylphenol (2), 2,5-dihydroxy-4-methoxyacetophenone (3), 2,3-dihydroxy-4-methoxyacetophenone (4), acetoveratrone (5), 2,5-dimethoxyhydroquinone (6), vanillic acid (7), resacetophenone (8), m-acetylphenol (9) and 3,5-dimethoxyhydroquinone (10). The protective effect of compounds 1-10 against glutamate-induced cytotoxicity in hippocampal HT22 cell line was evaluated. Among them, compound 4 showed a relatively effective protection of 47.55% (at 10 μM). This result suggested that compounds 4 had neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells.
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KEYWORD
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Cynanchum paniculatum Kitagawa, Neuroprotective activity, 2, 3-Dihydroxy-4-methoxyacetophenone
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